I like the fact that I can basically shoot psuedo-Super 16 but I'm experimenting with upscaling methods for lower res 600d DNGs and I'm finding it's best to batch upscale first in PS and not do it in AE (or your NLE). I'm also looking into algorithms. Bicubic is best for upscaling. Not sure what PS uses but I'm gonna try OnOne's Perfect Resize. It might cause weird artifacts though as it processes each shot independently.
What is After Effects, it's probably using the algorithm "Bilinear". Photoshop works with Bicubic, a little better, but still bad for our application.
The OnOne algorithm works by triangulating areas ... is good, but gives strong halo and is slow.
It seems to me that the best interpolation algorithm at the moment, for our case, is the Lanczos.
Test the "Lanczos4Resize", as Avisynth installed, and opening in VirtualDubmod ... you will see a big difference in this.
After Lancsos, could work with "Spline", the best so far, working with 256 points, but it is slow.
Someone trying Smooth-Spline?