I've found the bit rate multiplier use to depend on a number of factors, of roughly the same importance:
1. Sound on/off
2. Speed of SD or CF card
3. ISO
4. Light (daylight/indoor)
5. Action within the frame
For this reason, I think you likely will become frustrated if you think that there are any clear rules as to when a specific a multiplier will always work. For example, using a Sandisk Extreme 45 MB/s SD card: I have reliably recorded at 2.4x on my 600D in most daylight, at low ISO (100 or 160), with sound off; I have reliably recorded at 2.0x indoors, low key, at low ISO, with sound on; I have reliably recorded at 3.0x indoors, low key, low ISO, with sound off... But, I have also had recording stop in almost all of those situations at some point.
I also had a 5D Mark II for a weekend and used a Lexar UDMA 7 1000 MB/s card. While I didn't test it nearly as much as the 600D, I had about the same experiences, except that it did stop on me at 2.3x in bright sunlight.
Here's a link to a test I just posted if anyone is interested to see the benefits of the CBR multiplier: